How do the ingredients in Congaplex support the immune system?

Congaplex contains vitamins A and C, calcium, and magnesium to support immune system function.*

Vitamin A plays an important role in a healthy immune system by facilitating the development of type 1 and type 2 helper T cells as well as contributing to the function of both T cells and B cells. 1

Vitamin C enhances the healthy function of the immune system by supporting the maturation of T cells. 2 Additionally, vitamin C stimulates the functions of leukocytes and is important in natural killer (NK) cell activity. 3 Vitamin C supports the maintenance and regeneration of cells. 4

It has been shown that for effective T cell activation as well as T cell-dependent immune system response, it is critical to have both Ca 2+ signaling and the rearrangement of the cytoskeletal components of the cell to support that signaling. 5

Research findings suggest an inverse relationship between magnesium levels and the presence of C-reactive protein in blood. C-reactive protein levels are used by doctors as an indicator of inflammation status in the body. 6

Laboratory research by Standard Process scientists concluded that T lymphocyte cells treated with Congaplex showed statistically significant changes in cytokine levels and an increase in T cell signaling in a dose-dependent manner. 7*

How do the ingredients in Congaplex support the thymus gland?

Congaplex contains Cytosol™ extract from the bovine thymus gland to support the healthy function of human thymus gland. T cells are produced in the thymus gland and are very important for a healthy immune system response. 8*

How is ribonucleic acid (RNA) used to support cells experiencing a challenge

Cells require a steady supply of nucleotides to properly build RNA molecules to perform important functions such as protein synthesis and message delivery in cells.

Research has indicated that it is important to have nucleotides readily available to tissues that are experiencing stress. It is thought that during these times of stress the cells require more raw materials, such as nucleotides, to maintain health. More clinical research in adults is needed to better understand the role of dietary nucleotides and immune system response. 9*

What did the Standard Process research and development team discover when studying Immuplex® and Congaplex?

In a 2009 publication, Standard Process scientists reported that in T cell cultures, Immuplex reduced T cell “discussions” and calmed cell signaling. Congaplex increased T cell signaling in a dose-dependent manner. In the mix of human white blood cells, both supplements reacted similarly, suggesting that with the complexity of multiple immune signals, these supplements act in a far more adaptogenic manner. In other words, these supplements work with the complex immune system response instead of simply upregulating or downregulating cell signals. Cell culture is a very simplified way to study these effects and comes with serious limitations. But it does provide a starting point for future investigation and interesting hypotheses related to the underlying mechanism of action for Congaplex and Immuplex.*

• 1. Haryanto B, Suksmasari T, Wintergerst E, Maggini S. 2015. Multivitamin Supplementation Supports Immune Function and Ameliorates Conditions Triggered By Reduced Air Quality. Vitam Miner 4:2.

• 2. Manning J, Mitchell B, et al. 2013. Vitamin C Promotes Maturation of T-Cells. Antiox Redox Signal. 19:2054-2067.

• 3. Haryanto B, Suksmasari T, Wintergerst E, Maggini S. 2015. Multivitamin Supplementation Supports Immune Function and Ameliorates Conditions Triggered By Reduced Air Quality. Vitam Miner 4:2.

• 4. Ibid.

• 5. Joseph N, Reicher B, Barda-Saad M. 2014. The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux. Biochim Biophys Acta. 1838(2):557-68.

• 6. Nielsen FH. 2010. Magnesium, inflammation, and obesity in chronic disease. Nutrition Reviews® Vol. 68(6):333–340.

• 7. Hanlon PR, Robbins MG, Scholl C, Barnes DM. 2009. Aqueous extracts from dietary supplements influence the production of inflammatory cytokines in immortalized and primary T lymphocytes. BMC Complementary and Alternative Medicine. 9:51

• 8. Gould, R. Supporting the Body with Glandular Extracts. Nutri News 71.

• 9. Hess JR, Greenberg NA. 2012. The Role of Nucleotides in the Immune and Gastrointestinal Systems: Potential Clinical Applications. Nutrition in Clinical Practice. Vol. 27(2): 281-294.

Why suggest Congaplex for your patients?

• Congaplex contains essential vitamins and minerals that support immune system health, along with other nutrients to promote antioxidant activity.

• Alfalfa has been used traditionally to support health in many ways. Adrenal glands, kidney, and bovine bone provide nutrients that give nutritional support to the corresponding organs in humans.

• Veal bone is a complex raw material. In animals, as in humans, bones support white and red blood cell generation and act as a depot for minerals needed by the body. The veal bone PMG™ extract is designed to support human bone health.*

Synergistic Product Support

• Echinacea C

Complementary Educational Tools

• Immune System Support Brochure

• Immune Health Handout

• Immune Display Stand Insert

• Studying the Effect of Congaplex on T Cell Response Scientific Literature

Whole Food Nutrient Solutions

Since 1929, Standard Process has been the visionary leader in whole food nutrient solutions. We apply systems thinking to holistic nutrition that empowers practitioners to transform lives. Dedicated to the whole food philosophy of our founder, Dr. Royal Lee, our goal is to carry on his mission to provide nutrients for the body that are as close as possible to how they are found in nature.

Our products include foods that are prepared in a way that safeguards their nutritional value. The majority of these ingredients are grown locally on our certified organic farm and may require chopping, dicing, juicing, and/or drying for use in our products. The resulting whole food ingredients are then added to a formula that may include whole food extracts, animal tissue extracts and concentrates, botanicals, whole food isolates, and synthetic ingredients. These highly complex combinations contain a variety of elements designed to trigger trophic effects that support the body’s healthy balance and wellness.*

Suggested Use: Three capsules per meal, or as directed.

Supplement Facts

Serving Size: 3 CapsulesServings per Container: 30 or 50

Amount per Serving%DV

Calories5 

Total Carbohydrate1 g<1%*

Vitamin A900 IU20%

Vitamin C6 mg10%

Calcium80 mg8%

Magnesium15 mg4%

Proprietary Blend: 638 mg Bovine thymus Cytosol™ extract†, ribonucleic acid†, bovine bone†, carrot (root)†, nutritional yeast†, defatted wheat (germ)†, bovine adrenal†, sweet potato†,dried alfalfa (whole plant) juice†, oat flour†, alfalfa flour†, bovine kidney†, veal bone†, veal bone PMG™ extract†, mushroom†, dried buckwheat (leaf) juice†, buckwheat (seed)†, rice (bran)†, sunflower lecithin†, vitamin E (sunflower), and carrot oil†.

*Percent Daily Values (DV) based on a 2,000 calorie diet.

†Daily Value (DV) not established.

Other Ingredients: Calcium lactate, gelatin, magnesium citrate, water, ascorbic acid, calcium stearate, arabic gum, starch, sucrose (beets), and vitamin A palmitate.

Please consult the actual product label for the most accurate product information.

Congaplex Research Study

In a series of cell-culture experiments using immortalized T cells, Standard Process researchers showed that Congaplex affected signals produced by white blood cells. When a substance that provokes an immune response (antigen) is detected by T cells, these immune sentinels release cytokines (like IL-2 or TNF-α) that direct the action of the immune system. Cytokine production increased in the cells supplemented with Congaplex. Further research is needed to determine whether these same effects occur in the human body.